ConferCare


Conference timetable at a glance

Day 1 (Sat 21st July)

Day 2 (Sun 22nd July)

Day 3 (Mon 23rd July)

Day 4 (Tues 24th July)

9:00-9:30, PL1 (Farshid Guilak)

9:30-10:00, PL2 (Janine Erler)

9:00-9:30, PL4 (Joanne Murphy-Ullrich)

9:30-10:00, PL5 (Andy Blanchard)

9:00-10:45,

Dick Heinegård Young Investigator Award presentations (6x15')

10:00-10:45 Coffee break

10:00-10:45 Coffee break

10:45-11:30 Coffee break

10:45-12:30

Workshop 1

Stem Cells and Matrix Engineering

(2×20' lnvited

+ 4×15' STs)

10:45-12:30

Workshop 2

Fibrillar/Matricellular Signalling

(2×20' lnvited

+ 4×15' STs)

10:45-12:30

Workshop 5

ASMB sponsor session:

Pathobiology & Therapeutics to Fibrosis

(2×20' lnvited

+ 4×15' STs)

10:45-12:30

Workshop 6

Mechanisms of Matrix Disease

(2×20' lnvited

+ 4×15' STs)

11:30-12:30

PL7 (Erhard Hohenester)

2x15' Hot topic STs

12:30-14:30 Lunch/Posters

(14:15-14:30 Group photo)

12:30-14:30 Lunch/Posters

(14:00-14:30 BSMB AGM)

12:30-13:40 MBE AGM/Prizes/Closing ceremony/Lunch

Registration: 16:00-20:00

14:30-16:10

Workshop 3

Rhythms and Matrix Dynamics

(2×20' lnvited

+ 4×15' STs)

14:30-16:10

Workshop 4

ECM Microenvironment, Adhesion and Cell Fate

(2×20' lnvited

+ 4×15' STs)

14:30-16:10

Workshop 7

The Immunology/Matrix Interface

(2×20' lnvited

+ 4×15' STs)

14:30-16:10

Workshop 8

Matrix Mechanobiology

(2×20' lnvited

+ 4×15' STs)

14:30-16:30

BSMB Committee meeting

16:10-16:40 Tea break

16:10-16:40 Tea break

Opening Ceremony: 17:30-18:00

Keynote Lecture:

Reinhard Fässler

18:00-19:00

Welcome Reception: 19:00-21:00

Manchester Museum

16:40-17:10 PL3 (Taina Pihlajaniemi)

16:40-17:30 PL6 (Fell Muir Award: Ray Boot-Handford) followed by reception

17:10-18:00 Rupert Timpl Award followed by reception

17:30-18:00 MBE Reps committee meeting

Free time

Post-doc/PhD social

19:30-23:00

Conference Dinner (Old Trafford)

(STs, selected talks)

Final Programme

Click here for the full conference handbook.

MBE 2018 will be held in Manchester from July 21 to July 24 2018. The conference will include 6 plenary sessions and 8 workshops each centred on a specific theme of Matrix Biology, plus the BSMB Fell-Muir Award Lecture, the ISMB Rupert Timpl Award Lecture and the Dick Heinegård Young Investigator Award Session….plus talks from selected abstracts and posters galore….

Saturday 21st July 2018

16.00-20.00 Registration

Plenary Session 1

Chairperson: Ray Boot-Handford

18.00 – 18.10 Opening Remarks and Welcome

18.10 – 18.50 Reinhard Fässler (MaxPlanck, Martinsried, Germany) Keynote Address, ‘The Kindlin Universe’

19.00 – 21.00 Welcome Reception in Manchester Museum

Sunday 22nd July 2018

Plenary Session 2

Chairperson: Kim Midwood

9.00 – 9.30 Farshid Guilak (Washington Uni, USA): ‘Engineering new biologic therapies for arthritis’

9.30 – 10.00 Janine Erler (BRIC Copenhagen, Denmark): ‘ECM remodelling during cancer progression’

10.00 – 10.50 Coffee break

10.50 – 12.30 Workshop 1: Stem cells and Matrix Engineering

Chairperson: John Bateman

10.50 – 11.10 Gerjo van Osch (Erasmus MC, Netherland): ‘Adult human Mesenchymal Stem Cells; heterogeneity and cartilage matrix engineering capacity’

11.10 – 11.25 Tom Hodgkinson (U of Glasgow, UK) Identification and in vitro screening of osteogenic metabolites through supplement-free nanovibration-driven mesenchymal stem cell differentiation

11.25 – 11.40 Wai Kit Tam (HKU, Hong kong) Deriving Nucleus Pulposus-like Progenitors from MAP kinase Interference Coupled Chondrogenic Induction in Mesenchymal stem cells

11.40 - 11.55 Stefanie Korntner (NUI Galway, Ireland) In vivo wound healing with an engineered matrix-rich living modular construct for stem cell delivery

11.55 – 12.10 Aggie Turlo (U of Liverpool, UK) Insulin-like growth factor binding protein (Igfbp6) is a cross-species transcriptomic tendon marker

12.10 – 12.30 Dimitrios Zeugolis (NUI Galway, Ireland): ‘Extracellular matrix rich supramolecular assemblies in regenerative medicine’

10.50 - 12.30 Workshop 2: Fibrillar/Matricellular Signalling

Chairperson: Patricia Rousselle

10.50 – 11.10 Laurent Duca (Reims, France): ‘Elastin modification during vascular aging and pathophysiological consequences’

11.10 – 11.25 Michael P. Lockhart-Cairns (WCCMR, Manchester UK) The Structure and Regulation of latent TGFβ by LTBP1 and Fibrillin

11.25 – 11.40 Sylvie Ricard-Blum (U of Lyon.1, France) Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners

11.40 - 11.55 Suneel Apte (Cleveland, USA) Recycled secreted metalloproteases are required for formation of the primary cilium and hedgehog signalling

11.55 - 12.10 Giulia Taraboletti (IRCCS, Bergamo Italy) The interaction of thrombospondin-1 and -2 with FGF2 in the control of tumor angiogenesis

12.10 – 12.30 Wei Kong (PKUHSC, Beijing China): ‘Cartilage Oligomeric Matrix Protein Interactome in Vascular Homeostasis’

12.30 – 14.30 LUNCH and POSTERS

14.30 – 16.10 Workshop 3: Rhythms and Matrix Dynamics

Chairperson: Qing-Jun Meng

14.30 – 14.50 Karl Kadler (WCCMR, Manchester UK) ‘On the existence of a circadian matrix that is mechanoprotective and able to respond quickly to injury’

14.50 – 15.05 Yutaka Matsubayashi (Kings, London, UK) Distribution and production logistics for de novo basement membrane formation

15.05 – 15.20 Michal Dudek (WCCMR, Manchester UK) The role of the circadian clock in the homeostasis of the extracellular matrix in cartilage and intervertebral discs

15.20 – 15.35 Vanja Pekovic-Vaughan (U of Liverpool, UK) Abnormal fibrillinogenesis leads to disruption of clock gene regulation and reveals an important role for fibrillar matrix in the maintenance of circadian rhythmicity

15.35 – 15.50 Adam Pickard (WCCMR, Manchester UK) Monitoring collagen fibre formation and turnover using CRISPR/Cas9 knock-in of Dendra2

15.50 – 16.10 Kazuhiro Yagita (Kyoto, Japan): ‘Regulation and mis-regulation of cellular differentiation-coupled circadian clock functionality in mammals’

14.30 – 16.10 Workshop 4: ECM Microenvironment, Adhesion and Cell Fate

Chairperson: James Whiteford & Laura Collins

14.30 – 14.50 Christa Maes (KU Leuven, Belgium): ‘Osteolineage Cells’

14.50 – 15.05 Hong Qian (Karolinska, Stockholm Sweden) Laminin α4 deletion leads to impaired hematopoietic regeneration following irradiation-induced injury and accelerates the progression of acute myeloid leukemia

15.05 – 15.20 Adam Byron (U of Edinburgh, UK) Kindlin-1 regulates the mammary tumour cell secretome.

15.20 – 15.35 Kati Drushinin (Biocentre Oulu, Finland) Collagen prolyl 4-hydroxylases in collagen fibril formation and wound healing in mouse skin.

15.35 – 15.50 Satsuki Mochizuki (National Defense Medical College, Japan) Development of human antibody against ADAM28, a key modulator of tumor microenvironmental factors in non-small cell lung carcinomas

15.50 – 16.10 Alberto Passi (U of Insubria, Italy): ‘Epigenetic control of hyaluronan synthesis’

16.10 – 16.40 Tea Break

Plenary Session 3

Chairperson: Liliana Schaefer

16.40 – 17.10 Taina Pihlajaniemi (U of Oulu, Finland): Collagen XVIII and its contributions to development of tissues and tumourigenesis

17:10 – 17:20 ISMB Award to David Hulmes

17.20 – 18.00 ISMB Rupert Timpl Award Lecture, Sponsored by Elsevier / Matrix Biology (followed by Reception)

Alexandra Naba (Uni of Illinois at Chicago, USA) The Matrisome Project: bioinformatic and proteomic tools to study the ECM in health and disease

Monday 23rd July

Plenary Session 4

Chairperson: Sylvie Ricard-Blum

9.00 – 9.30 Joanne Murphy-Ullrich (U of Alabama at Birmingham, USA): The ER stress and calcium regulatory protein calreticulin in fibrosis in diabetic nephropathy

9.30 – 10.00 Andy Blanchard (GSK Stevenage, UK): ‘Translating research to therapies for lung fibrosis’

10.00 – 10.50 Coffee break

10.50 – 12.30 Workshop 5: ASMB sponsored session: Pathobiology and Therapeutics to Fibrosis

Chairperson: Joanne Murphy-Ullrich

10.50 – 11.10 Rebecca Wells (UPenn, USA): ‘The effect of a complex matrix on the mechanics of liver fibrosis’

11.10 – 11.25 George Bou-Gharios (U of Liverpool, UK) Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival

11.25 – 11.40 Valentina Masola (U of Padova, Italy) Inhibition of heparanase protects against renal failure and fibrosis following ischemia/reperfusion

11.40 - 11.55 Marc Tatar (Brown Univ, USA) Extra-cellular matrix induced by aldosterone through a G-protein coupled receptor revealed in a novel Drosophila model of renal fibrosis

11.55 - 12.10 Shaun Fell (Aston Univ, UK) The importance of tissue transglutaminase for the deposition of matrix proteins in idiopathic pulmonary fibrosis

12.10 – 12.30 Tom Barker (U of Virginia, USA): ‘Post-translational modifications of Fibronectin as therapeutic targets for Fibrosis?’

10.50 – 12.30 Workshop 6: Mechanisms of Matrix Disease

Chairperson: Kathy Cheah

10.50 – 11.10 Nikos Karamanos (U of Patras, Greece): ‘ERs as regulators of ECM: from epigenetics to breast cancer cell behaviour’

11.10 – 11.25 Francesca Tonelli (U of Pavia, Italy) New Zebrafish models for recessive osteogenesis imperfecta

11.25 – 11.40 Jamie Soul (WCCMR, Manchester UK) Understanding skeletal disease with cross-species transcriptomics meta-analysis

11.40 - 11.55 Anna Köhler (U of Cologne, Germany) Ablation of epidermal collagen chaperoning by Hsp47 results in dermal fibrosis

11.55 - 12.10 Johanne Dubail (INSERM UMR1163, Paris France) SLC10A7 mutations in human and mouse cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects.

12.10 – 12.30 Mike Briggs (U of Newcastle): ‘New therapeutic targets in genetic skeletal diseases’

12.30 – 14.30 LUNCH and POSTERS

14.30 – 16.10 Workshop 7: The Immunology/Matrix Interface

Chairperson: John Whitelock

14.30 – 14.50 Liliana Schaefer (Goethe Univ, Germany): ‘Small leucine-rich proteoglycans in inflammation: two sides of the coin’

14.50 – 15.05 Victor Martinez (UCL, UK) Leukocyte control of matrix deposition in the lymph node

15.05 – 15.20 Anja Schwenzer (KIR, Oxford Univ, UK) Post-translational modifications of the extracellular matrix: key events in disease pathogenesis

15.20 – 15.35 Caroline Milner (U of Manchester, UK) TSG-6 modulates chondrocyte phenotype in osteoarthritis by suppressing inflammatory signals that promote cartilage breakdown

15.35 – 15.50 Douglas Dyer (U of Glasgow, UK) Leukocyte migration and inflammatory disease: the collaboration between endothelial sugars and chemokines

15.50 – 16.10 Judi Allen (WCCMR, Manchester UK): ‘Regulation of Matrix by Type 2 cytokines: Learning from Helminths’

14.30 – 16.10 Workshop 8: Matrix Mechanobiology

Chairperson: Checco Ramirez & Michal Dudek

14.30 – 14.50 Viola Vogel (ETH Zürich, Switzerland) “Mechanobiology of Extracellular Matrix Fibers in vitro and in vivo”

14.50 – 15.05 Mukti Singh (WCCMR, Manchester UK) Structure and interactions of elastic fibre proteins ADAMTSL2 and ADAMTSL4.

15.05 – 15.20 Emma Blain (Cardiff Univ. UK) Mechano-regulation of miRNA-221, -222, -21 and -27: implications for articular cartilage homeostasis

15.20 – 15.35 Marion Marchand (CNRS Paris, France) Extracellular matrix scaffolding: impact on vascular morphogenesis and endothelial mechanotransduction

15.35 – 15.50 Joe Swift (WCCMR, Manchester UK) Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

15.50 – 16.10 Maria Dolores Martin Bermudo (Sevilla, Spain): ‘Cellular contractility controlled by cell-ECM interactions sculpt organs and tissues’

16.10 – 16.40 Tea Break

16.40 – 17.30 Plenary Session 5

BSMB Fell-Muir Award, sponsored by The Int. Journal Experimental Pathology (followed by Reception)

Chairperson John Couchman

Ray Boot-Handford (WCCMR, Manchester UK): Gene cloning to clinical trials - the trials and tribulations of a life with collagen

18.30 Manchester United Stadium Tour

19.30 Conference Dinner at MU Stadium

Details of coaches to and from stadium will be given at the conference.

Tuesday 24th July 2018

9.00 – 10.45 Dick Heinegård Young Investigator Award Session

9.00 – 9.05 Introductory comments by Chairman of Heinegård YIA committee

9.05 – 9.25 Raphael Reuten representing The German Society for Matrix Biology BRIC, University of Copenhagen, Denmark

“Modulating the physico-mechanical properties of basement membranes through the extracellular-matrix protein netrin-4”

9.25 – 9.45 René Brüggebusch Svensson representing The Danish Soc. Matrix Biol. Institute of Sports Medicine Copenhagen, Denmark

“Mechanical properties of collagen fibrils in tendon”

9.45 – 10.05 Andrea Lolli representing The Dutch Society for Matrix Biology Erasmus University Medical Center, Netherlands

“Hydrogel-based delivery of antiMir-221 enhances cartilage matrix production by endogenous cells: towards microRNA therapy for cartilage repair”

10.05 – 10.25 Ching-Yan Chloé Yeung representing The British Soc. Matrix Biology Institute of Sports Medicine Copenhagen, Denmark

“Regulation of tissue homeostasis by the tendon clock”

10.25 – 10.45 Karl Emil Tykesson representing The Swedish Connective Tissue Soc. Lund University, Lund, Sweden

"Crystal structure of dermatan sulfate epimerase 1 and its interaction with dermatan 4-sulfotransferase 1"

10.45 – 11.30 Coffee Break

11.30 – 12.30 Plenary Session 6

Chairperson Karl Kadler

11.30 – 12.00 Erhard Hohenester (Imperial College London): ‘Biosynthesis and function of (honorary) glycosaminoglycans: insights from structural studies’

Hot Topics

12.00 – 12.15 Frank Gondelaud (U of Lyon 1, France) Structural characterization of the ectodomains of the four human syndecans

12.15 – 12.30 Tom van Agtmael (U of Glasgow, UK) Targeting ER stress in Col4a1 mutant mice reduces intracerebral haemorrhaging and highlights tissue specific disease mechanisms

12.30- 13.10 MBE AGM, Prizes, closing ceremony

Chairman John Couchman BSMB

13.10 – 13.40 Lunch and departure

14:00 – 18:00 Satellite Workshop run by Alvéole, in collaboration with Manchester University (Michael Smith Building)

Further details here

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